Pharmaceutical and nutraceutical development often involves compounds that are difficult to formulate due to poor solubility, thermal sensitivity, or chemical instability. While spray drying, hot melt extrusion, and crystallization have their place, they often fall short for sensitive or scarce actives. Bulk lyophilization offers a compelling alternative: a low-temperature, solvent-minimizing process that stabilizes even fragile compounds without sacrificing yield or performance.
In this white paper, you’ll explore how bulk lyophilization is being used to stabilize and enable difficult-to-deliver APIs across multiple fields. Learn where it outperforms conventional drying methods, how it fits into early-phase development, and why leading formulation teams are increasingly turning to it to improve bioavailability, extend shelf life, and support novel delivery formats.